Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer
The objective of this study was to evaluate the clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer (CRC). A total of 108 patients with CRC who underwent curative surgery and 20 healthy volunteers were enrolled in this study. ADP-ribosyl...
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| Veröffentlicht in: | Tumor biology 2014-06, Vol.35 (6), p.5575-5582 |
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| creator | Varol, Başak Coşkun, Özlem Karabulut, Senem Serin, Kürşat Rahmi Asoğlu, Oktar Albeniz, Işıl Taş, Faruk Nurten, Rüstem |
| description | The objective of this study was to evaluate the clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer (CRC). A total of 108 patients with CRC who underwent curative surgery and 20 healthy volunteers were enrolled in this study. ADP-ribosylation and NAD glycohydrolase activity levels were determined. The association of ADP-ribosylation and NAD glycohydrolase with clinical and laboratory factors and their impact on overall survival (OS) and disease free survival (DFS) were shown. The preoperative ADP-ribosylation and NAD glycohydrolase activity levels were significantly higher in patients with CRC than in the control group (
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| doi_str_mv | 10.1007/s13277-014-1735-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1535632583</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3331476711</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-88e60b2f4534c42258897f0459d015439daaefe0c2076a3523c8e56c8ea096e53</originalsourceid><addsrcrecordid>eNp1kctqHDEQRUVIiJ8f4E0QZJONEj1b3cthnDgBY3thr4VGXT2W0UgTqduh_96ajBOMwRupoE7delyEzhj9yijV3woTXGtCmSRMC0XYO3TIJBeEipa-rzFllEjeigN0VMoDpUx1XfMRHXCphNK6O0R5GXz0zgZc_Dr6oYbRAU4DLpCnDV6c35DsV6nMwY4-RWxjj68W53gdZpfu5z6nYAtg60b_6McZ-4i3lYQ4FvzHj_fYpZAyuLG2-KudT9CHwYYCp8__Mbr78f12-ZNcXl_8Wi4uiZOSj6RtoaErPtRRpZOcq7bt9ECl6vq6hxRdby0MQB2nurFCceFaUE19LO0aUOIYfdnrbnP6PUEZzcYXByHYCGkqhtUbNKLqiop-foU-pCnHOt2OkpqLjtFKsT3lciolw2C22W9sng2jZmeI2RtiqiFmZ4hhtebTs_K02kD_v-KfAxXge6DUVFxDftH6TdUnnJWVqw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1534723910</pqid></control><display><type>article</type><title>Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Varol, Başak ; Coşkun, Özlem ; Karabulut, Senem ; Serin, Kürşat Rahmi ; Asoğlu, Oktar ; Albeniz, Işıl ; Taş, Faruk ; Nurten, Rüstem</creator><creatorcontrib>Varol, Başak ; Coşkun, Özlem ; Karabulut, Senem ; Serin, Kürşat Rahmi ; Asoğlu, Oktar ; Albeniz, Işıl ; Taş, Faruk ; Nurten, Rüstem</creatorcontrib><description><![CDATA[The objective of this study was to evaluate the clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer (CRC). A total of 108 patients with CRC who underwent curative surgery and 20 healthy volunteers were enrolled in this study. ADP-ribosylation and NAD glycohydrolase activity levels were determined. The association of ADP-ribosylation and NAD glycohydrolase with clinical and laboratory factors and their impact on overall survival (OS) and disease free survival (DFS) were shown. The preoperative ADP-ribosylation and NAD glycohydrolase activity levels were significantly higher in patients with CRC than in the control group (
p
< 0.001). ADP-ribosylation and NAD glycohydrolase activity levels were correlated with tumor stage (
p
= 0.05,
p
= 0.001), stage of disease (
p
< 0.001,
p
< 0.001), serum CEA level (
p
< 0.001,
p
< 0.001), and site of lesion (
p
< 0.001,
p
< 0.001), respectively. Patients with high ADP-ribosylation had significantly unfavorable OS and DFS compared with those with lower levels (
p
< 0.001,
p
< 0.001), respectively. Moreover, the patients with high NAD glycohydrolase activity showed significantly worse OS and DFS rates, similar to ADP-ribosylation. Serum levels of ADP-ribosylation and NAD glycohydrolase activity correlate well with tumor stage, stage of disease, serum CEA level, and site of lesion. In conclusion, elevated levels of preoperative ADP-ribosylation and NAD glycohydrolase levels in serum are associated with poor prognosis in patients with CRC.]]></description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-014-1735-1</identifier><identifier>PMID: 24535779</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adenosine Diphosphate - metabolism ; Adult ; Aged ; Aged, 80 and over ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Carcinoembryonic Antigen - blood ; Cellular biology ; Colorectal cancer ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Disease-Free Survival ; Enzymes ; Female ; Humans ; Male ; Medical prognosis ; Middle Aged ; NAD+ Nucleosidase - blood ; Neoplasm Staging ; Research Article</subject><ispartof>Tumor biology, 2014-06, Vol.35 (6), p.5575-5582</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-88e60b2f4534c42258897f0459d015439daaefe0c2076a3523c8e56c8ea096e53</citedby><cites>FETCH-LOGICAL-c442t-88e60b2f4534c42258897f0459d015439daaefe0c2076a3523c8e56c8ea096e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-014-1735-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-014-1735-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24535779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Varol, Başak</creatorcontrib><creatorcontrib>Coşkun, Özlem</creatorcontrib><creatorcontrib>Karabulut, Senem</creatorcontrib><creatorcontrib>Serin, Kürşat Rahmi</creatorcontrib><creatorcontrib>Asoğlu, Oktar</creatorcontrib><creatorcontrib>Albeniz, Işıl</creatorcontrib><creatorcontrib>Taş, Faruk</creatorcontrib><creatorcontrib>Nurten, Rüstem</creatorcontrib><title>Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description><![CDATA[The objective of this study was to evaluate the clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer (CRC). A total of 108 patients with CRC who underwent curative surgery and 20 healthy volunteers were enrolled in this study. ADP-ribosylation and NAD glycohydrolase activity levels were determined. The association of ADP-ribosylation and NAD glycohydrolase with clinical and laboratory factors and their impact on overall survival (OS) and disease free survival (DFS) were shown. The preoperative ADP-ribosylation and NAD glycohydrolase activity levels were significantly higher in patients with CRC than in the control group (
p
< 0.001). ADP-ribosylation and NAD glycohydrolase activity levels were correlated with tumor stage (
p
= 0.05,
p
= 0.001), stage of disease (
p
< 0.001,
p
< 0.001), serum CEA level (
p
< 0.001,
p
< 0.001), and site of lesion (
p
< 0.001,
p
< 0.001), respectively. Patients with high ADP-ribosylation had significantly unfavorable OS and DFS compared with those with lower levels (
p
< 0.001,
p
< 0.001), respectively. Moreover, the patients with high NAD glycohydrolase activity showed significantly worse OS and DFS rates, similar to ADP-ribosylation. Serum levels of ADP-ribosylation and NAD glycohydrolase activity correlate well with tumor stage, stage of disease, serum CEA level, and site of lesion. In conclusion, elevated levels of preoperative ADP-ribosylation and NAD glycohydrolase levels in serum are associated with poor prognosis in patients with CRC.]]></description><subject>Adenosine Diphosphate - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>Cellular biology</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Disease-Free Survival</subject><subject>Enzymes</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>NAD+ Nucleosidase - blood</subject><subject>Neoplasm Staging</subject><subject>Research Article</subject><issn>1010-4283</issn><issn>1423-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kctqHDEQRUVIiJ8f4E0QZJONEj1b3cthnDgBY3thr4VGXT2W0UgTqduh_96ajBOMwRupoE7delyEzhj9yijV3woTXGtCmSRMC0XYO3TIJBeEipa-rzFllEjeigN0VMoDpUx1XfMRHXCphNK6O0R5GXz0zgZc_Dr6oYbRAU4DLpCnDV6c35DsV6nMwY4-RWxjj68W53gdZpfu5z6nYAtg60b_6McZ-4i3lYQ4FvzHj_fYpZAyuLG2-KudT9CHwYYCp8__Mbr78f12-ZNcXl_8Wi4uiZOSj6RtoaErPtRRpZOcq7bt9ECl6vq6hxRdby0MQB2nurFCceFaUE19LO0aUOIYfdnrbnP6PUEZzcYXByHYCGkqhtUbNKLqiop-foU-pCnHOt2OkpqLjtFKsT3lciolw2C22W9sng2jZmeI2RtiqiFmZ4hhtebTs_K02kD_v-KfAxXge6DUVFxDftH6TdUnnJWVqw</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Varol, Başak</creator><creator>Coşkun, Özlem</creator><creator>Karabulut, Senem</creator><creator>Serin, Kürşat Rahmi</creator><creator>Asoğlu, Oktar</creator><creator>Albeniz, Işıl</creator><creator>Taş, Faruk</creator><creator>Nurten, Rüstem</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20140601</creationdate><title>Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer</title><author>Varol, Başak ; Coşkun, Özlem ; Karabulut, Senem ; Serin, Kürşat Rahmi ; Asoğlu, Oktar ; Albeniz, Işıl ; Taş, Faruk ; Nurten, Rüstem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-88e60b2f4534c42258897f0459d015439daaefe0c2076a3523c8e56c8ea096e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenosine Diphosphate - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Carcinoembryonic Antigen - blood</topic><topic>Cellular biology</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Disease-Free Survival</topic><topic>Enzymes</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>NAD+ Nucleosidase - blood</topic><topic>Neoplasm Staging</topic><topic>Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Varol, Başak</creatorcontrib><creatorcontrib>Coşkun, Özlem</creatorcontrib><creatorcontrib>Karabulut, Senem</creatorcontrib><creatorcontrib>Serin, Kürşat Rahmi</creatorcontrib><creatorcontrib>Asoğlu, Oktar</creatorcontrib><creatorcontrib>Albeniz, Işıl</creatorcontrib><creatorcontrib>Taş, Faruk</creatorcontrib><creatorcontrib>Nurten, Rüstem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Varol, Başak</au><au>Coşkun, Özlem</au><au>Karabulut, Senem</au><au>Serin, Kürşat Rahmi</au><au>Asoğlu, Oktar</au><au>Albeniz, Işıl</au><au>Taş, Faruk</au><au>Nurten, Rüstem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>35</volume><issue>6</issue><spage>5575</spage><epage>5582</epage><pages>5575-5582</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract><![CDATA[The objective of this study was to evaluate the clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer (CRC). A total of 108 patients with CRC who underwent curative surgery and 20 healthy volunteers were enrolled in this study. ADP-ribosylation and NAD glycohydrolase activity levels were determined. The association of ADP-ribosylation and NAD glycohydrolase with clinical and laboratory factors and their impact on overall survival (OS) and disease free survival (DFS) were shown. The preoperative ADP-ribosylation and NAD glycohydrolase activity levels were significantly higher in patients with CRC than in the control group (
p
< 0.001). ADP-ribosylation and NAD glycohydrolase activity levels were correlated with tumor stage (
p
= 0.05,
p
= 0.001), stage of disease (
p
< 0.001,
p
< 0.001), serum CEA level (
p
< 0.001,
p
< 0.001), and site of lesion (
p
< 0.001,
p
< 0.001), respectively. Patients with high ADP-ribosylation had significantly unfavorable OS and DFS compared with those with lower levels (
p
< 0.001,
p
< 0.001), respectively. Moreover, the patients with high NAD glycohydrolase activity showed significantly worse OS and DFS rates, similar to ADP-ribosylation. Serum levels of ADP-ribosylation and NAD glycohydrolase activity correlate well with tumor stage, stage of disease, serum CEA level, and site of lesion. In conclusion, elevated levels of preoperative ADP-ribosylation and NAD glycohydrolase levels in serum are associated with poor prognosis in patients with CRC.]]></abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24535779</pmid><doi>10.1007/s13277-014-1735-1</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Tumor biology, 2014-06, Vol.35 (6), p.5575-5582 |
| issn | 1010-4283 1423-0380 |
| language | eng |
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| subjects | Adenosine Diphosphate - metabolism Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Research Carcinoembryonic Antigen - blood Cellular biology Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Disease-Free Survival Enzymes Female Humans Male Medical prognosis Middle Aged NAD+ Nucleosidase - blood Neoplasm Staging Research Article |
| title | Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer |
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