Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer

The objective of this study was to evaluate the clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer (CRC). A total of 108 patients with CRC who underwent curative surgery and 20 healthy volunteers were enrolled in this study. ADP-ribosyl...

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Veröffentlicht in:	Tumor biology 2014-06, Vol.35 (6), p.5575-5582
Hauptverfasser:	Varol, Başak, Coşkun, Özlem, Karabulut, Senem, Serin, Kürşat Rahmi, Asoğlu, Oktar, Albeniz, Işıl, Taş, Faruk, Nurten, Rüstem
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Research Carcinoembryonic Antigen - blood Cellular biology Colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Disease-Free Survival Enzymes Female Humans Male Medical prognosis Middle Aged NAD+ Nucleosidase - blood Neoplasm Staging Research Article
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Zusammenfassung:	The objective of this study was to evaluate the clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer (CRC). A total of 108 patients with CRC who underwent curative surgery and 20 healthy volunteers were enrolled in this study. ADP-ribosylation and NAD glycohydrolase activity levels were determined. The association of ADP-ribosylation and NAD glycohydrolase with clinical and laboratory factors and their impact on overall survival (OS) and disease free survival (DFS) were shown. The preoperative ADP-ribosylation and NAD glycohydrolase activity levels were significantly higher in patients with CRC than in the control group ( p
ISSN:	1010-4283 1423-0380
DOI:	10.1007/s13277-014-1735-1