Agitation-induced aggregation and subvisible particulate formation in model proteins

[Display omitted] The kinetics of agitation-induced subvisible particle formation was investigated for a few model proteins – human serum albumin (HSA), hen egg white lysozyme (HEWL), and a monoclonal antibody (IgG2). Experiments were carried out for the first time under relatively low protein conce...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2014-07, Vol.87 (2), p.299-309
Hauptverfasser:	Jayaraman, Murali, Buck, Patrick M., Alphonse Ignatius, Arun, King, Kevin R., Wang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Agitation Animals Antibodies, Monoclonal - chemistry Chickens Hot Temperature Humans Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Immunoglobulin G - chemistry Kinetics Molecular Weight Muramidase - chemistry Particle Particle Size Protein Protein Conformation Protein Stability Serum Albumin - chemistry Serum Albumin, Human Solubility Stability Surface Properties Unfolding
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!