Genome-wide association study in musician's dystonia: A risk variant at the arylsulfatase G locus?

Genome-wide association study in musician's dystonia: A risk variant at the arylsulfatase G locus?

ABSTRACT Musician's dystonia (MD) affects 1% to 2% of professional musicians and frequently terminates performance careers. It is characterized by loss of voluntary motor control when playing the instrument. Little is known about genetic risk factors, although MD or writer's dystonia (WD)...

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Veröffentlicht in:Movement disorders 2014-06, Vol.29 (7), p.921-927
Hauptverfasser: Lohmann, Katja, Schmidt, Alexander, Schillert, Arne, Winkler, Susen, Albanese, Alberto, Baas, Frank, Bentivoglio, Anna Rita, Borngräber, Friederike, Brüggemann, Norbert, Defazio, Giovanni, Del Sorbo, Francesca, Deuschl, Günther, Edwards, Mark J., Gasser, Thomas, Gómez-Garre, Pilar, Graf, Julia, Groen, Justus L., Grünewald, Anne, Hagenah, Johann, Hemmelmann, Claudia, Jabusch, Hans-Christian, Kaji, Ryuji, Kasten, Meike, Kawakami, Hideshi, Kostic, Vladimir S., Liguori, Maria, Mir, Pablo, Münchau, Alexander, Ricchiuti, Felicia, Schreiber, Stefan, Siegesmund, Katharina, Svetel, Marina, Tijssen, Marina A.J., Valente, Enza Maria, Westenberger, Ana, Zeuner, Kirsten E., Zittel, Simone, Altenmüller, Eckart, Ziegler, Andreas, Klein, Christine
Format: Artikel
Sprache:eng
Schlagworte:
Arylsulfatases - genetics
association study
Confidence intervals
dystonia
Dystonic Disorders - genetics
Genes
Genetic Loci
Genetic Predisposition to Disease
Genetic Testing - methods
Genome-Wide Association Study
Genomes
Humans
Movement disorders
Musicians & conductors
Polymorphism
Psychomotor Performance - physiology
Risk
risk factor
Risk Factors
sulfatase
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Zusammenfassung:ABSTRACT Musician's dystonia (MD) affects 1% to 2% of professional musicians and frequently terminates performance careers. It is characterized by loss of voluntary motor control when playing the instrument. Little is known about genetic risk factors, although MD or writer's dystonia (WD) occurs in relatives of 20% of MD patients. We conducted a 2‐stage genome‐wide association study in whites. Genotypes at 557,620 single‐nucleotide polymorphisms (SNPs) passed stringent quality control for 127 patients and 984 controls. Ten SNPs revealed P 
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.25791