Clinical Evaluation of Vancomycin Dosage in Pediatric Oncology Patients

Vancomycin trough serum concentrations were below therapeutic range (8–15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients 12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.

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Veröffentlicht in:	The Pediatric infectious disease journal 2014-07, Vol.33 (7), p.731-733
Hauptverfasser:	Sanders, Stefan J.W.J, Bijleveld, Yuma A, Sinkeler, Fleur, Kemper, Elles M, Pajkrt, Dasja, van de Wetering, Marianne, van Eijkelenburg, Natasha K.A, Mathôt, Ron A.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Infections - drug therapy Biological and medical sciences Child Child, Preschool Female Humans Infant Infectious diseases Male Medical sciences Neoplasms - complications Pharmacology. Drug treatments Retrospective Studies Serum - chemistry Vancomycin - administration & dosage Vancomycin - pharmacokinetics Vancomycin - pharmacology
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Beschreibung
Zusammenfassung:	Vancomycin trough serum concentrations were below therapeutic range (8–15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients 12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0000000000000268