Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up

It is hypothesized that CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) can prevent destruction of pancreatic islets protecting from type 1 diabetes (DM1). Here we present results of one year follow-up of 12 DM1 children treated with autologous expanded ex vivo Tregs. Patients received either a sin...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.) Fla.), 2014-07, Vol.153 (1), p.23-30
Hauptverfasser: Marek-Trzonkowska, Natalia, Myśliwiec, Małgorzata, Dobyszuk, Anita, Grabowska, Marcelina, Derkowska, Ilona, Juścińska, Jolanta, Owczuk, Radosław, Szadkowska, Agnieszka, Witkowski, Piotr, Młynarski, Wojciech, Jarosz-Chobot, Przemysława, Bossowski, Artur, Siebert, Janusz, Trzonkowski, Piotr
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Sprache:eng
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Zusammenfassung:It is hypothesized that CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) can prevent destruction of pancreatic islets protecting from type 1 diabetes (DM1). Here we present results of one year follow-up of 12 DM1 children treated with autologous expanded ex vivo Tregs. Patients received either a single or double Tregs infusion up to the total dose of 30×10(6)/kg. No severe adverse effects were observed. The treatment did not impair post-immunization antibody responses. Tregs infusion was followed by increase in Tregs number in peripheral blood. Most of the patients responded to the therapy with increase in C-peptide levels (8/12 and 4/6 after the first and the second dose, respectively). Tregs administration resulted also in lower requirement for exogenous insulin (8/12 treated patients versus 2/10 untreated controls in remission) with two children completely insulin independent at one year. Repetitive administration of Tregs is safe and can prolong survival of β-cells in DM1 (registration: ISRCTN06128462).
ISSN:1521-7035
DOI:10.1016/j.clim.2014.03.016