Evaluation of the developmental toxicity of succinate tartrates in rats

The potential for succinate tartrates (ST) to induce developmental toxicity in Sprague-Dawley CD rats has been evaluated. ST dose levels of 250, 500 and 1000 mg/kg body weight/day were administered in the drinking-water on days 6–15 of gestation. Control animals received distilled water. Caesarean s...

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Veröffentlicht in:	Food and chemical toxicology 1989, Vol.27 (4), p.249-253
Hauptverfasser:	Petersen, D.W., Daston, G.P., Schardein, J.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - etiology Animals Biological and medical sciences Body Weight - drug effects Chelating Agents dosage Drinking Eating Embryology: invertebrates and vertebrates. Teratology Female fetal development Fundamental and applied biological sciences. Psychology gestation period Gestational Age Male Pregnancy Rats Rats, Inbred Strains Statistics as Topic Succinates - toxicity succinic acid Teratology. Teratogens toxicity water
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Zusammenfassung:	The potential for succinate tartrates (ST) to induce developmental toxicity in Sprague-Dawley CD rats has been evaluated. ST dose levels of 250, 500 and 1000 mg/kg body weight/day were administered in the drinking-water on days 6–15 of gestation. Control animals received distilled water. Caesarean sections were performed on gestation day 20 and the foetuses were removed for teratological evaluation. No significant maternal or developmental toxicity was observed at any dose level. Based on these observations, the no-observed-effect level for ST developmental toxicity is greater than or equal to 1 g/kg/day, which was the highest dose tested.
ISSN:	0278-6915 1873-6351
DOI:	10.1016/0278-6915(89)90163-4