Charybdotoxin blocks both Ca-activated K channels and Ca-independent voltage-gated K channels in rat brain synaptosomes

Charybdotoxin (ChTX), a 4.3 kDa polypeptide toxin from the venom of the scorpion Leiurus quinquestriatus, blocks both a Ca-activated K channel (IC 50 ≈ 15 nM) and a Ca-independent voltage-gated K channel (IC 50 ≈ 40 nM) in rat brain synaptosomes. These results indicate that in this preparation ChTX...

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Veröffentlicht in:	FEBS letters 1989-07, Vol.250 (2), p.433-436
Hauptverfasser:	Schneider, M.J., Rogowski, R.S., Krueger, B.K., Blaustein, M.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-AP, 4-aminopyridine Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Brain - drug effects Calcium - pharmacology Charybdotoxin ChTX, charybdotoxin Fundamental and applied biological sciences. Psychology K + channel Miscellaneous NTX, noxiustoxin PCP, phencyclidine (1-[1-cyclohexyl] piperazine) Potassium Channels - drug effects Proteins Rats Scorpion Venoms - toxicity Synaptosome Synaptosomes - drug effects TEA, tetraethylammonium α-DaTX, α-dendrotoxin
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Beschreibung
Zusammenfassung:	Charybdotoxin (ChTX), a 4.3 kDa polypeptide toxin from the venom of the scorpion Leiurus quinquestriatus, blocks both a Ca-activated K channel (IC 50 ≈ 15 nM) and a Ca-independent voltage-gated K channel (IC 50 ≈ 40 nM) in rat brain synaptosomes. These results indicate that in this preparation ChTX is not specific for the Ca-activated K channel and suggest that there may be structural homology among the toxin-binding sites on various types of K channels.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(89)80771-9