Characterization of the binding of ( super(3)H)L-365,260: A new potent and selective brain cholecystokinin (CCK-B) and gastrin receptor antagonist radioligand

Characterization of the binding of ( super(3)H)L-365,260: A new potent and selective brain cholecystokinin (CCK-B) and gastrin receptor antagonist radioligand

( super(3)H)L-365, 260, ((3R-(+)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin- 3-yl)-N'-(3-methylphenyl)urea), a new potent and selective nonpeptide brain cholecystokinin (CCK-B) and gastrin receptor antagonist, bound saturably and reversibly to guinea pig brain membranes. Scatchard...

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Veröffentlicht in:Molecular pharmacology 1989-01, Vol.35 (6), p.803-808
Hauptverfasser: Chang, RSL, Chen, T B, Bock, M G, Freidinger, R M, Chen, R, Rosegay, A, Lotti, V J
Format: Artikel
Sprache:eng
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Zusammenfassung:( super(3)H)L-365, 260, ((3R-(+)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin- 3-yl)-N'-(3-methylphenyl)urea), a new potent and selective nonpeptide brain cholecystokinin (CCK-B) and gastrin receptor antagonist, bound saturably and reversibly to guinea pig brain membranes. Scatchard analysis indicated a single class of high affinity binding sites. The data indicates that ( super(3)H)L-365,260 represents a new potent nonpeptide antagonist radioligand suitable for the study of brain CCK-B and gastrin receptors.
ISSN:0026-895X