A coumarin-quinolinium-based fluorescent probe for ratiometric sensing of sulfite in living cells

Based on a novel coumarin-quinolinium platform, probe 2 was rationally designed and synthesized as a novel ratiometric fluorescent sensor for sulfite anions. The probe exhibited a wide dynamic concentration range for sulfite anions in a PBS buffer (containing 1 mg mL(-1) BSA). More importantly, the...

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Veröffentlicht in:	Organic & biomolecular chemistry 2014-07, Vol.12 (26), p.4637-4643
Hauptverfasser:	Tan, Li, Lin, Weiying, Zhu, Sasa, Yuan, Lin, Zheng, Kaibo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biosensing Techniques - methods Cell Survival Coumarins - chemistry Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Macrophages - metabolism Mice Models, Molecular Proton Magnetic Resonance Spectroscopy Quantum Theory Quinolinium Compounds - chemistry Spectrometry, Fluorescence Sulfites - analysis Time Factors
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Beschreibung
Zusammenfassung:	Based on a novel coumarin-quinolinium platform, probe 2 was rationally designed and synthesized as a novel ratiometric fluorescent sensor for sulfite anions. The probe exhibited a wide dynamic concentration range for sulfite anions in a PBS buffer (containing 1 mg mL(-1) BSA). More importantly, the probe was suitable for ratiometric fluorescence imaging in living cells with high sensitivity, favorable selectivity, and minimal cytotoxicity.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/c4ob00132j