Clinical Characteristics of Patients who Developed Hepatocellular Carcinoma after Hepatitis C Virus Eradication with Interferon Therapy: Current Status in Japan

Objective We attempted to elucidate the clinical features of chronic hepatitis C patients who develop hepatocellular carcinoma (HCC) after achieving a sustained viral response (SVR) to interferon (IFN) therapy. Methods The clinical features of 130 patients at 19 hospitals who developed HCC after obt...

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Veröffentlicht in:	Internal Medicine 2013, Vol.52(24), pp.2701-2706
Hauptverfasser:	Sato, Akira, Sata, Michio, Ikeda, Kenji, Kumada, Takashi, Izumi, Namiki, Asahina, Yasuhiro, Osaki, Yukio, Chayama, Kazuaki, Kaneko, Shuichi, Sakai, Akito, Onji, Morikazu, Hiasa, Yoichi, Omura, Takumi, Ozeki, Itaru, Yokosuka, Osamu, Shiina, Shuichiro, Itsubo, Mariko, Nishiguchi, Shuhei, Hirano, Katsuharu, Ide, Tatsuya, Sakisaka, Shotaro, Yamasaki, Takahiro, Hidaka, Isao, Tanaka, Masatoshi, Kim, Soo Ryang, Ichida, Takafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Carcinoma, Hepatocellular - chemically induced Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - epidemiology Female Follow-Up Studies Hepatitis C virus Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - epidemiology hepatocellular carcinoma Humans interferon Interferons - adverse effects Interferons - therapeutic use Japan - epidemiology Liver Neoplasms - chemically induced Liver Neoplasms - diagnosis Liver Neoplasms - epidemiology Male Middle Aged Retrospective Studies sustained viral response Treatment Outcome Viral Load - drug effects
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Zusammenfassung:	Objective We attempted to elucidate the clinical features of chronic hepatitis C patients who develop hepatocellular carcinoma (HCC) after achieving a sustained viral response (SVR) to interferon (IFN) therapy. Methods The clinical features of 130 patients at 19 hospitals who developed HCC after obtaining an SVR were retrospectively reviewed. Results Overall, 107 (82%) of the 130 patients were men, with 92 (71%) being ≥60 years of age and 76, 38 and 16 developing HCC within 5, 5-10 and 10-16.9 years after IFN therapy, respectively. Before receiving IFN therapy, 92 (71%) patients had cirrhosis and/or a low platelet count (
ISSN:	0918-2918 1349-7235
DOI:	10.2169/internalmedicine.52.1180