Plasma Ndel1 enzyme activity is reduced in patients with schizophrenia – A potential biomarker?

Abstract Ndel1 oligopeptidase interacts with schizophrenia (SCZ) risk gene product DISC1 and mediates several functions related to neurite outgrowth and neuronal migration. Ndel1 also hydrolyzes neuropeptides previously implicated in SCZ, namely neurotensin and bradykinin. Herein, we compared the pl...

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Veröffentlicht in:	Journal of psychiatric research 2013-05, Vol.47 (5), p.657-663
Hauptverfasser:	Gadelha, Ary, Machado, Mauricio F.M, Yonamine, Camila M, Sato, João R, Juliano, Maria A, Oliveira, Vitor, Bressan, Rodrigo A, Hayashi, Mirian A.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Antipsychotic drugs Axonogenesis Biological and medical sciences Biological markers Biomarker Biomarkers - blood Carrier Proteins - blood Enzyme activity Female Fluorometry Genes Humans Male Medical sciences Middle Aged Migration Neuropeptide Oligopeptidase Plasma Plasma - enzymology Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses ROC Curve Schizophrenia Schizophrenia - blood Treatment
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Zusammenfassung:	Abstract Ndel1 oligopeptidase interacts with schizophrenia (SCZ) risk gene product DISC1 and mediates several functions related to neurite outgrowth and neuronal migration. Ndel1 also hydrolyzes neuropeptides previously implicated in SCZ, namely neurotensin and bradykinin. Herein, we compared the plasma Ndel1 enzyme activity of 92 SCZ patients and 96 healthy controls (HCs). Ndel1 enzyme activity was determined by fluorimetric measurements of the FRET peptide substrate Abz-GFSPFRQ-EDDnp hydrolysis rate. A 31% lower mean value for Ndel1 activity was observed in SCZ patients compared to HCs (Student's t = 4.36; p
ISSN:	0022-3956 1879-1379
DOI:	10.1016/j.jpsychires.2013.01.009