Sex determines which section of the SLC6A4 gene is linked to obsessive–compulsive symptoms in normal Chinese college students

Abstract Previous case–control and family-based association studies have implicated the SLC6A4 gene in obsessive–compulsive disorder (OCD). Little research, however, has examined this gene's role in obsessive–compulsive symptoms (OCS) in community samples. The present study genotyped seven tag...

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Veröffentlicht in:	Journal of psychiatric research 2012-09, Vol.46 (9), p.1153-1160
Hauptverfasser:	Lei, Xuemei, Chen, Chuansheng, He, Qinghua, Chen, Chunhui, Moyzis, Robert K, Xue, Gui, Chen, Xiongying, Cao, Zhongyu, Li, Jin, Li, He, Zhu, Bi, Chun Hsu, Anna Shan, Li, Sufang, Li, Jun, Dong, Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HTTLPR Adult and adolescent clinical studies Anxiety Anxiety disorders. Neuroses Asian Continental Ancestry Group - genetics Biological and medical sciences Female Gender Gender differences Genes Genetic Predisposition to Disease Haplotype Humans Linkage Disequilibrium Male Medical sciences Obsessive-Compulsive Disorder - genetics Obsessive-Compulsive Disorder - physiopathology Obsessive-compulsive disorders Obsessive-Compulsive neuroses Obsessive–compulsive disorder Obsessive–compulsive symptoms Polymorphism, Single Nucleotide - genetics Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serotonin Plasma Membrane Transport Proteins - genetics Sex Characteristics SLC6A4 STin2 Stressful events Students Symptoms Undergraduate students Universities Young Adult
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Zusammenfassung:	Abstract Previous case–control and family-based association studies have implicated the SLC6A4 gene in obsessive–compulsive disorder (OCD). Little research, however, has examined this gene's role in obsessive–compulsive symptoms (OCS) in community samples. The present study genotyped seven tag SNPs and two common functional tandem repeat polymorphisms ( 5-HTTLPR and STin2 ), which together cover the whole SLC6A4 gene, and investigated their associations with OCS in normal Chinese college students ( N = 572). The results revealed a significant gender main effect and gender-specific genetic effects of the SLC6A4 gene on OCS. Males scored significantly higher on total OCS and its three dimensions than did females ( ps
ISSN:	0022-3956 1879-1379
DOI:	10.1016/j.jpsychires.2012.05.002