Geranylphenazinediol, an Acetylcholinesterase Inhibitor Produced by a Streptomyces Species

Geranylphenazinediol (1), a new phenazine natural product, was produced by the Streptomyces sp. strain LB173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data. 1 inhibited the enzyme acetylcholinesterase in the low micromolar range and sh...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2012-07, Vol.75 (7), p.1400-1404
Hauptverfasser:	Ohlendorf, Birgit, Schulz, Dirk, Erhard, Arlette, Nagel, Kerstin, Imhoff, Johannes F
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Bacillus subtilis - drug effects Candida albicans - drug effects Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology Fibroblasts - drug effects Humans Microbial Sensitivity Tests Molecular Structure Nuclear Magnetic Resonance, Biomolecular Phenazines - chemistry Phenazines - isolation & purification Phenazines - pharmacology Streptomyces Streptomyces - chemistry Xanthomonas campestris - drug effects
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Zusammenfassung:	Geranylphenazinediol (1), a new phenazine natural product, was produced by the Streptomyces sp. strain LB173, which was isolated from a marine sediment sample. The structure was established by analysis of NMR and MS data. 1 inhibited the enzyme acetylcholinesterase in the low micromolar range and showed weak antibacterial activity. In order to get a more detailed picture of the activity profile of 1, its inhibitory potential was compared to that of related structures.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np2009626