Differential expression pattern of microRNAs in CD4+ and CD19+ cells from asymptomatic patients with systemic lupus erythematosus

Objective The aim of this study was to investigate the pattern of microRNA (miRNA) expression in CD19+ and CD4+ cells from asymptomatic patients with systemic lupus erythematosus (SLE). Methods A screening of the expression of 377 miRNAs was performed in human CD4+ and CD19+ cells isolated from the...

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Veröffentlicht in:	Lupus 2014-04, Vol.23 (4), p.353-359
Hauptverfasser:	Martínez-Ramos, R, García-Lozano, J-R, Lucena, J-M, Castillo-Palma, M-J, García-Hernández, F, Rodríguez, M-C, Núñez-Roldán, A, González-Escribano, M-F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, CD19 - metabolism Asymptomatic Blood & organ donations Case-Control Studies CD4-Positive T-Lymphocytes - metabolism Cells Cytokines Disease Female Gene Expression Profiling Gene Expression Regulation Hospitals Humans Investigations Lupus Lupus Erythematosus, Systemic - genetics Male MicroRNAs MicroRNAs - genetics Middle Aged Oligonucleotide Array Sequence Analysis - methods
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Zusammenfassung:	Objective The aim of this study was to investigate the pattern of microRNA (miRNA) expression in CD19+ and CD4+ cells from asymptomatic patients with systemic lupus erythematosus (SLE). Methods A screening of the expression of 377 miRNAs was performed in human CD4+ and CD19+ cells isolated from the peripheral blood by using a TaqMan Human MicroRNA Array. Validation of differential expression pattern of those was performed using TaqMan assays in these cell populations obtained from a larger cohort of patients and controls. Results According to the screening assays, three miRNAs were differentially expressed (p value
ISSN:	0961-2033 1477-0962
DOI:	10.1177/0961203314522335