Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome

Glioblastoma is the most common brain tumor. Median survival in unselected patients is

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Veröffentlicht in:	Experimental cell research 2013-08, Vol.319 (14), p.2230-2243
Hauptverfasser:	Sandberg, Cecilie Jonsgar, Altschuler, Gabriel, Jeong, Jieun, Strømme, Kirsten Kierulf, Stangeland, Biljana, Murrell, Wayne, Grasmo-Wendler, Unn-Hilde, Myklebost, Ola, Helseth, Eirik, Vik-Mo, Einar Osland, Hide, Winston, Langmoen, Iver A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult human neural stem cell Aged Brain cancer Brain Neoplasms - diagnosis Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer stem cell Case-Control Studies Cellular biology Clinical outcomes Embryonic Stem Cells - metabolism Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genome, Human Glioblastoma Glioblastoma - diagnosis Glioblastoma - metabolism Glioblastoma - pathology Humans Induced Pluripotent Stem Cells - metabolism Middle Aged Neoplastic Stem Cells - metabolism Neural Stem Cells - metabolism Prognosis Sfrp1 Signal transduction Stem cells Survival Transcription, Genetic Up-Regulation Wnt Wnt Signaling Pathway - genetics
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Zusammenfassung:	Glioblastoma is the most common brain tumor. Median survival in unselected patients is
ISSN:	0014-4827 1090-2422
DOI:	10.1016/j.yexcr.2013.06.004