EUCAST Technical Note on Candida and micafungin, anidulafungin and fluconazole

Summary The European Committee on Antimicrobial Susceptibility Testing Subcommittee on Antifungal Susceptibility Testing has determined breakpoints for micafungin and revised breakpoints for anidulafungin and fluconazole for Candida spp. This Technical Note is based on the corresponding rationale do...

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Veröffentlicht in:Mycoses 2014-06, Vol.57 (6), p.377-379
Hauptverfasser: Cavling Arendrup, Maiken, Cuenca-Estrella, Manuel, Lass-Flörl, Cornelia, Hope, William W.
Format: Artikel
Sprache:eng
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Zusammenfassung:Summary The European Committee on Antimicrobial Susceptibility Testing Subcommittee on Antifungal Susceptibility Testing has determined breakpoints for micafungin and revised breakpoints for anidulafungin and fluconazole for Candida spp. This Technical Note is based on the corresponding rationale documents (http://www.eucast.org). The micafungin breakpoints are based on PK data, animal PK/PD data, microbiological data and clinical experience. The anidulafungin breakpoints for C. parapsilosis and fluconazole breakpoints for C. glabrata have been modified to species‐specific values that categorise the wild‐type as intermediate to accommodate use of these compounds in some clinical situations.
ISSN:0933-7407
1439-0507
DOI:10.1111/myc.12170