Phoslactomycins from Streptomyces sp. MLA1839 and Their Biological Activities

Phoslactomycins H (1) and I (2), two new members of the phoslactomycin class of chemistry, were isolated from Streptomyces sp. MLA1839 on the basis of their antifungal activities. Their structures were elucidated using extensive NMR spectroscopy and mass spectrometry. Phoslactomycin H (1) featured a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2013-08, Vol.76 (8), p.1509-1513
Hauptverfasser:	Fotso, Serge, Graupner, Paul, Xiong, Quanbo, Hahn, Don, Avila-Adame, Cruz, Davis, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Organophosphorus Compounds - chemistry Organophosphorus Compounds - isolation & purification Organophosphorus Compounds - pharmacology Streptomyces Streptomyces - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Phoslactomycins H (1) and I (2), two new members of the phoslactomycin class of chemistry, were isolated from Streptomyces sp. MLA1839 on the basis of their antifungal activities. Their structures were elucidated using extensive NMR spectroscopy and mass spectrometry. Phoslactomycin H (1) featured a rare and unprecedented N,N-dimethylamine substitution at C-4 and existed as a hydroxy acid rather than the more common lactone. Herein, we report the structure of these compounds and their biological activities.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np400232j