Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells

Methionine sulfoxide reductase B3 (MsrB3) is a protein repair enzyme that specifically reduces methionine-R-sulfoxide to methionine. A recent genetic study showed that the MSRB3 gene is associated with autosomal recessive hearing loss in human deafness DFNB74. However, the precise role of MSRB3 in t...

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Veröffentlicht in:Human molecular genetics 2014-03, Vol.23 (6), p.1591-1601
Hauptverfasser: Kwon, Tae-Jun, Cho, Hyun-Ju, Kim, Un-Kyung, Lee, Eujin, Oh, Se-Kyung, Bok, Jinwoong, Bae, Yong Chul, Yi, Jun-Koo, Lee, Jang Woo, Ryoo, Zae-Young, Lee, Sang Heun, Lee, Kyu-Yup, Kim, Hwa-Young
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Sprache:eng
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