Cepharanthine inhibited HIV-1 cell–cell transmission and cell-free infection via modification of cell membrane fluidity

The anti-HIV-1 activity of cepharanthine (CEP), a natural product derived from Stephania cepharantha Hayata, was evaluated. CEP stabilized plasma membrane fluidity and inhibited HIV-1 envelope-dependent cell-to-cell fusion of HIV-1-infected cells as well as cell-free infection. It is suggested that...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-05, Vol.24 (9), p.2115-2117
Hauptverfasser:	Matsuda, Kouki, Hattori, Shinichiro, Komizu, Yuji, Kariya, Ryusho, Ueoka, Ryuichi, Okada, Seiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzylisoquinolines - isolation & purification Benzylisoquinolines - pharmacology Cell fusion Cells, Cultured Cepharanthine HEK293 Cells HIV Fusion Inhibitors - isolation & purification HIV Fusion Inhibitors - pharmacology HIV Infections - prevention & control HIV Infections - transmission HIV Infections - virology HIV-1 HIV-1 - drug effects HIV-1 - physiology Host-Pathogen Interactions - drug effects Human immunodeficiency virus 1 Humans Jurkat Cells Lymphocytes - virology Membrane fluidity Membrane Fluidity - drug effects Stephania - chemistry Viral infection Virus Internalization - drug effects
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Zusammenfassung:	The anti-HIV-1 activity of cepharanthine (CEP), a natural product derived from Stephania cepharantha Hayata, was evaluated. CEP stabilized plasma membrane fluidity and inhibited HIV-1 envelope-dependent cell-to-cell fusion of HIV-1-infected cells as well as cell-free infection. It is suggested that CEP inhibited the HIV-1 entry process by reducing plasma membrane fluidity, and the plasma membrane is therefore an identical target to prevent viral infection.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2014.03.041