Multiple epimutations in imprinted genes in the human genome and congenital disorders

The current knowledge on multiple epimutations in imprinted genes and their impact on the disturbance of human prenatal development and the emergence of hereditary diseases are reviewed and analyzed. Genetic mechanisms regulating the epigenetic state of imprinted loci in the human genome are discuss...

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Veröffentlicht in:	Russian journal of genetics 2014-03, Vol.50 (3), p.221-236
Hauptverfasser:	Lepshin, M. V, Sazhenova, E. A, Lebedev, I. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine genes genetic disorders Human Genetics humans loci Microbial Genetics and Genomics prenatal development Reviews and Theoretical Articles
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Beschreibung
Zusammenfassung:	The current knowledge on multiple epimutations in imprinted genes and their impact on the disturbance of human prenatal development and the emergence of hereditary diseases are reviewed and analyzed. Genetic mechanisms regulating the epigenetic state of imprinted loci in the human genome are discussed.
ISSN:	1022-7954 1608-3369
DOI:	10.1134/S1022795414030053