Does enhancement of oxidative stress markers mediate health effects of ambient air particles?

Evidence indicates that oxidative stress generation may contribute to health effects associated with particulate matter (PM) exposure. We investigated oxidative stress markers in 113 workers exposed to metal-rich PM and 61 nonexposed comparable volunteers. The plasma levels of soluble NOX2-derived p...

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Veröffentlicht in:	Antioxidants & redox signaling 2014-07, Vol.21 (1), p.46-51
Hauptverfasser:	Bertazzi, Pier Alberto, Cantone, Laura, Pignatelli, Pasquale, Angelici, Laura, Bollati, Valentina, Bonzini, Matteo, Carugno, Michele, Mannucci, Pier Mannuccio, Violi, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult alpha-Tocopherol - blood Biomarkers - blood Biomarkers - urine Deoxyguanosine - analogs & derivatives Deoxyguanosine - urine Dinoprost - analogs & derivatives Dinoprost - urine Humans Male Middle Aged Multivariate Analysis Oxidative Stress - drug effects Particulate Matter - toxicity Regression Analysis Young Adult
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Zusammenfassung:	Evidence indicates that oxidative stress generation may contribute to health effects associated with particulate matter (PM) exposure. We investigated oxidative stress markers in 113 workers exposed to metal-rich PM and 61 nonexposed comparable volunteers. The plasma levels of soluble NOX2-derived peptide (sNOX2-dp) and two oxidative stress markers, urinary 8-hydroxydeoxyguanosine (8-OHdG) and 8-iso-prostaglandinF2alpha (8-iso-PGF2α), were analyzed. The plasma levels of the antioxidant alpha-tocopherol were also evaluated. The workers' average exposure to PM with an aerodynamic diameter
ISSN:	1523-0864 1557-7716
DOI:	10.1089/ars.2013.5694