Integrin β3 links therapy resistance and cancer stem cell properties

Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin α v β 3 expression in multiple types of solid tumour stem cells is now shown to contro...

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Veröffentlicht in:	Nature cell biology 2014-05, Vol.16 (5), p.397-399
Hauptverfasser:	Kannan, Nagarajan, Nguyen, Long V., Eaves, Connie J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67 631/67/71 631/80/79/1236 631/80/86 Animals Cancer Cancer Research Care and treatment Cell Biology Developmental Biology Drug resistance Drug Resistance, Neoplasm Female Humans Integrin beta3 - metabolism Integrins Life Sciences Lung Neoplasms - drug therapy Neoplastic Stem Cells - drug effects news-and-views Properties Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins p21(ras) ral GTP-Binding Proteins - metabolism ras Proteins - metabolism Receptor, Epidermal Growth Factor - antagonists & inhibitors Stem Cells
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Zusammenfassung:	Heterogeneity in tumour cell properties underlies many treatment failures. Understanding the sources of such heterogeneity has proved to be challenging, but remains critical to improving patient outcomes. Integrin α v β 3 expression in multiple types of solid tumour stem cells is now shown to control a pro-survival pathway that contributes to therapy resistance.
ISSN:	1465-7392 1476-4679
DOI:	10.1038/ncb2960