Effect of chrysotile asbestos (AP-I) on sister chromatid exchanges in Chinese hamster ovary cells

Effect of chrysotile asbestos (AP-I) on sister chromatid exchanges in Chinese hamster ovary cells

In vitro effect of an Indian variety of chrysotile asbestos from Andhra Pradesh (AP-I) is evaluated using sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells. Cultures were treated for 24 hr with different concentrations of asbestos fibers, i.e., 0.1, 1, 10, and 100 μg/ml of mediu...

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Veröffentlicht in:Environmental research 1981-01, Vol.24 (2), p.325-329
Hauptverfasser: Babu, K.Aravinda, Nigam, S.K., Lakkad, B.C., Bhatt, D.K., Karnik, A.B., Thakore, K.N., Kashyap, S.K., Chatterjee, S.K.
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Sprache:eng
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Zusammenfassung:In vitro effect of an Indian variety of chrysotile asbestos from Andhra Pradesh (AP-I) is evaluated using sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells. Cultures were treated for 24 hr with different concentrations of asbestos fibers, i.e., 0.1, 1, 10, and 100 μg/ml of medium. Sister chromatid exchanges were elevated even with the lowest concentration used. However, the linear relationship between SCEs and asbestos concentration is not seen.
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(81)90162-6