Crizotinib and renal insufficiency: A case report and review of the literature

Abstract A 69 year old man with idiopathic chronic kidney disease was diagnosed with relapsing EGFR negative, ALK positive lung adenocarcinoma, and treated with chemotherapy and antiangiogenic treatment, under which his renal insufficiency worsened. During second line crizotinib treatment, further w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2014-06, Vol.84 (3), p.310-313
Hauptverfasser:	Martín Martorell, Paloma, Huerta Alvaro, Marisol, Solís Salguero, Miguel A, Insa Molla, Amelia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma of Lung Aged ALK Biological and medical sciences Crizotinib Hematology, Oncology and Palliative Medicine Humans Kidney Function Tests Lung adenocarcinoma Lung Neoplasms - drug therapy Male Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Pneumology Protein Kinase Inhibitors - adverse effects Pulmonary/Respiratory Pyrazoles - adverse effects Pyridines - adverse effects Renal failure Renal insufficiency Renal Insufficiency - chemically induced Toxicity Tumors Tumors of the respiratory system and mediastinum Tyrosine kinase inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract A 69 year old man with idiopathic chronic kidney disease was diagnosed with relapsing EGFR negative, ALK positive lung adenocarcinoma, and treated with chemotherapy and antiangiogenic treatment, under which his renal insufficiency worsened. During second line crizotinib treatment, further worsening of the renal function was seen, with very clear correlation with crizotinib withdrawal and rechallenge. No further drug causes for the worsening blood creatinine values were detected.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2014.03.001