The subtle allostery of microtubule dynamics

The subtle allostery of microtubule dynamics

New high-resolution structures of microtubules reveal that GTP and taxol each stimulate microtubule assembly by inducing straight protofilaments and promoting extension of the interdimer spacing. However, these effects take place through different mechanisms: GTP directly extends loops around the ac...

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Veröffentlicht in:Nature structural & molecular biology 2014-06, Vol.21 (6), p.505-506
Hauptverfasser: Amos, Linda A, Löwe, Jan
Format: Artikel
Sprache:eng
Schlagworte:
631/1647/2258/1258/1259
631/80/128/1653
Biochemistry
Biological Microscopy
Catalytic Domain
Cellular control mechanisms
Cryoelectron Microscopy
Crystal structure
Enzymes
Guanosine Triphosphate - metabolism
Guanosine Triphosphate - physiology
Life Sciences
Membrane Biology
Microtubules
Microtubules - chemistry
Microtubules - metabolism
Microtubules - ultrastructure
Molecular Conformation
news-and-views
Paclitaxel - metabolism
Properties
Protein Structure
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Beschreibung
Zusammenfassung:New high-resolution structures of microtubules reveal that GTP and taxol each stimulate microtubule assembly by inducing straight protofilaments and promoting extension of the interdimer spacing. However, these effects take place through different mechanisms: GTP directly extends loops around the active site, whereas taxol works like a remote lever.
ISSN:1545-9993
1545-9985
DOI:10.1038/nsmb.2836