Four‐year retention and risk factors for attrition among members of community ART groups in Tete, Mozambique
Objective Community ART groups (CAG), peer support groups involved in community ART distribution and mutual psychosocial support, were piloted to respond to staggering antiretroviral treatment (ART) attrition in Mozambique. To understand the impact of CAG on long‐term retention, we estimated mortali...
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Veröffentlicht in: | Tropical medicine & international health 2014-05, Vol.19 (5), p.514-521 |
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Sprache: | eng |
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Zusammenfassung: | Objective
Community ART groups (CAG), peer support groups involved in community ART distribution and mutual psychosocial support, were piloted to respond to staggering antiretroviral treatment (ART) attrition in Mozambique. To understand the impact of CAG on long‐term retention, we estimated mortality and lost‐to‐follow‐up (LTFU) rates and assessed predictors for attrition.
Methods
Retrospective cohort study. Kaplan–Meier techniques were used to estimate mortality and LTFU in CAG. Individual‐ and CAG‐level predictors of attrition were assessed using a multivariable Cox proportional hazards model, adjusted for site‐level clustering.
Results
Mortality and LTFU rates among 5729 CAG members were, respectively, 2.1 and 0.1 per 100 person‐years. Retention was 97.7% at 12 months, 96.0% at 24 months, 93.4% at 36 months and 91.8% at 48 months. At individual level, attrition in CAG was significantly associated with immunosuppression when joining a CAG, and being male. At CAG level, attrition was associated with lack of rotational representation at the clinic, lack of a regular CD4 count among fellow members and linkage to a rural or district clinic compared with linkage to a peri‐urban clinic.
Conclusions
Long‐term retention in this community‐based ART model compares favourably with published data on stable ART patients. Nevertheless, to reduce attrition, further efforts need to be made to enrol patients earlier on ART, promote health‐seeking behaviour, especially for men, promote a strong peer dynamic to assure rotational representation at the clinic and regular CD4 follow‐up and reinforce referral of sick patients.
Objectif
Les groupes ART communautaires (GAC), groupes de soutien par les pairs, impliqués dans la dispensation communautaire de l’ART et de soutien psychosocial mutuel, ont été mis à l'essai pour répondre à l'attrition stupéfiant dans le traitement antirétroviral (ART) au Mozambique. Pour comprendre l'impact des GAC sur la rétention à long terme, nous avons estimé les taux de mortalité et de perdus au suivi et avons évalué les facteurs prédictifs de l'attrition.
Méthodes
Il s'agit d'une étude de cohorte rétrospective. Les techniques de Kaplan‐Meier ont été utilisées pour estimer la mortalité et les perdus au suivi dans les GAC. Les prédicteurs de l'attrition à l’échelle individuels et des GAC ont été évalués en utilisant un modèle multivarié de risques proportionnels de Cox, ajustés pour le regroupement au niveau du site.
Résultats
Les taux de mortalit |
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ISSN: | 1360-2276 1365-3156 |
DOI: | 10.1111/tmi.12278 |