Synthesis of β‑C‑Galactosyl Ceramide and Its New Aza Variant via the Horner–Wadsworth–Emmons Reaction

Synthesis of β‑C‑Galactosyl Ceramide and Its New Aza Variant via the Horner–Wadsworth–Emmons Reaction

A simple strategy for the synthesis of β-C-galactosyl ceramide and its new aza-variant analogue is described using the Horner–Wadsworth–Emmons reaction as the key step in combining the sugar and aglycone portions.

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Veröffentlicht in:Journal of organic chemistry 2014-06, Vol.79 (11), p.5193-5200
Hauptverfasser: Gorantla, Jaggaiah N, Lankalapalli, Ravi S
Format: Artikel
Sprache:eng
Schlagworte:
Aza Compounds - chemical synthesis
Aza Compounds - chemistry
Galactosylceramides - chemical synthesis
Galactosylceramides - chemistry
Molecular Structure
Stereoisomerism
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Beschreibung
Zusammenfassung:A simple strategy for the synthesis of β-C-galactosyl ceramide and its new aza-variant analogue is described using the Horner–Wadsworth–Emmons reaction as the key step in combining the sugar and aglycone portions.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo500769f