SYNERGISTIC EFFECT OF THIAMPHENICOL AND CEPHALOTHIN ON BACTEROIDES FRAGILIS

Synergistic effect of thiamphenicol (TP) and cephalothin (CET) on Bacteroides fragilis was proved in vitro. Especially its effect was much clear on B. fragilis which is possible to produce β-lactamase. Synergistic bactericidal effect of TP and CET was proved. Chemotherapeutic effect of TP and CET ag...

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Veröffentlicht in:Japanese journal of antibiotics 1981/05/25, Vol.34(5), pp.647-650
Hauptverfasser: ISONO, MIDORI, AOKI, MAKOTO, KOBAYASHI, TOYOKO, MARUI, TOSHINORI, YAMADA, HISASHI, UMEMURA, ATSUSHI, WATANABE, KUNITOMO, UENO, KAZUE
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container_end_page 650
container_issue 5
container_start_page 647
container_title Japanese journal of antibiotics
container_volume 34
creator ISONO, MIDORI
AOKI, MAKOTO
KOBAYASHI, TOYOKO
MARUI, TOSHINORI
YAMADA, HISASHI
UMEMURA, ATSUSHI
WATANABE, KUNITOMO
UENO, KAZUE
description Synergistic effect of thiamphenicol (TP) and cephalothin (CET) on Bacteroides fragilis was proved in vitro. Especially its effect was much clear on B. fragilis which is possible to produce β-lactamase. Synergistic bactericidal effect of TP and CET was proved. Chemotherapeutic effect of TP and CET against experimental mixed infectious mouse due to E. coli (β-lactamase-) and B. fragilis (β-lactamase +) was proved.
doi_str_mv 10.11553/antibiotics1968b.34.647
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subjects Bacteroides fragilis
title SYNERGISTIC EFFECT OF THIAMPHENICOL AND CEPHALOTHIN ON BACTEROIDES FRAGILIS
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