Artificial metalloenzymes for enantioselective catalysis

•Recent advances in the field of artificial metalloenzymes with a particular focus on enantioselective catalysis are described.•New design strategies for artificial metalloenzymes are described.•Catalytic reactions using artificial metalloenzymes are shown, including reaction types that have no equivalent in conventional homogeneous or enzyme catalysis.•Trends and prospect of the use of artificial metalloenzymes in catalysis both in vitro and in vivo are discussed. Artificial metalloenzymes have emerged over the last decades as an attractive approach towards combining homogeneous catalysis and biocatalysis. A wide variety of catalytic transformations have been established by artificial metalloenzymes, thus establishing proof of concept. The field is now slowly transforming to take on new challenges. These include novel designs, novel catalytic reactions, some of which have no equivalent in both homogenous catalysis and biocatalysis and the incorporation of artificial metalloenzymes in chemoenzymatic cascades. Some of these developments represent promising steps towards integrating artificial metalloenzymes in biological systems. This review will focus on advances in this field and perspectives discussed.