Physiological doses of atrial peptide inhibit angiotensin II-stimulated aldosterone secretion

Physiological doses of atrial peptide inhibit angiotensin II-stimulated aldosterone secretion

The current study was designed to investigate the potential of atrial peptide t o serve as a physiological regulator of aldosterone secretion. Conscious chronically instrumented dogs were given a constant intravenous infusion of either atrial peptide or vehicle. The results suggest that normal varia...

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Veröffentlicht in:American Journal of Physiology: Cell Physiology 1989-01, Vol.256 (5), p.R1155-R1159
Hauptverfasser: Metzler, CH, Ramsay, D J
Format: Artikel
Sprache:eng
Schlagworte:
adrenal cortex
aldosterone
atrial natriuretic hormone
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Zusammenfassung:The current study was designed to investigate the potential of atrial peptide t o serve as a physiological regulator of aldosterone secretion. Conscious chronically instrumented dogs were given a constant intravenous infusion of either atrial peptide or vehicle. The results suggest that normal variations in plasma atrial peptide concentration can play an important role in the regulation of aldosterone secretion and fluid and electrolyte balance.
ISSN:0363-6143