Induction of DNA repair synthesis in isolated rat hepatocytes by 5-diazouracil and other DNA damaging compounds
5-Diazouracil, which has been recommended in cancer chemotherapy, induced DNA repair synthesis in isolated rat hepatocytes. Repair synthesis was determined by means of the bromodeoxyuridine (BrdUrd)-CsCl-gradient centrifugation method. The validity of this technique was demonstrated using various DN...
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| Veröffentlicht in: | Cancer letters 1981-01, Vol.13 (3), p.187-193 |
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| container_title | Cancer letters |
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| creator | Andrae, Ulrich Schwarz, Leslie R. |
| description | 5-Diazouracil, which has been recommended in cancer chemotherapy, induced DNA repair synthesis in isolated rat hepatocytes. Repair synthesis was determined by means of the bromodeoxyuridine (BrdUrd)-CsCl-gradient centrifugation method. The validity of this technique was demonstrated using various DNA damaging compounds. |
| doi_str_mv | 10.1016/0304-3835(81)90017-3 |
| format | Article |
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Repair synthesis was determined by means of the bromodeoxyuridine (BrdUrd)-CsCl-gradient centrifugation method. The validity of this technique was demonstrated using various DNA damaging compounds.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(81)90017-3</identifier><identifier>PMID: 6271392</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Benzo(a)pyrene ; Benzopyrenes - pharmacology ; Diazonium Compounds - pharmacology ; Dimethylnitrosamine - pharmacology ; DNA - biosynthesis ; DNA Repair ; Epoxy Compounds - pharmacology ; Liver - cytology ; Liver - drug effects ; Male ; Methyl Methanesulfonate - pharmacology ; Methylnitronitrosoguanidine - pharmacology ; Mutagens ; Rats ; Rats, Inbred Strains ; Uracil - analogs & derivatives ; Uracil - pharmacology</subject><ispartof>Cancer letters, 1981-01, Vol.13 (3), p.187-193</ispartof><rights>1981</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-4bc4a53bc9bfb68e5dd704afaeb659221872d2f112ab2b039cfb292097288f4b3</citedby><cites>FETCH-LOGICAL-c388t-4bc4a53bc9bfb68e5dd704afaeb659221872d2f112ab2b039cfb292097288f4b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0304383581900173$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6271392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andrae, Ulrich</creatorcontrib><creatorcontrib>Schwarz, Leslie R.</creatorcontrib><title>Induction of DNA repair synthesis in isolated rat hepatocytes by 5-diazouracil and other DNA damaging compounds</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>5-Diazouracil, which has been recommended in cancer chemotherapy, induced DNA repair synthesis in isolated rat hepatocytes. 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| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1981-01, Vol.13 (3), p.187-193 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15322286 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Benzo(a)pyrene Benzopyrenes - pharmacology Diazonium Compounds - pharmacology Dimethylnitrosamine - pharmacology DNA - biosynthesis DNA Repair Epoxy Compounds - pharmacology Liver - cytology Liver - drug effects Male Methyl Methanesulfonate - pharmacology Methylnitronitrosoguanidine - pharmacology Mutagens Rats Rats, Inbred Strains Uracil - analogs & derivatives Uracil - pharmacology |
| title | Induction of DNA repair synthesis in isolated rat hepatocytes by 5-diazouracil and other DNA damaging compounds |
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