Induction of DNA repair synthesis in isolated rat hepatocytes by 5-diazouracil and other DNA damaging compounds

5-Diazouracil, which has been recommended in cancer chemotherapy, induced DNA repair synthesis in isolated rat hepatocytes. Repair synthesis was determined by means of the bromodeoxyuridine (BrdUrd)-CsCl-gradient centrifugation method. The validity of this technique was demonstrated using various DN...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 1981-01, Vol.13 (3), p.187-193
Hauptverfasser:	Andrae, Ulrich, Schwarz, Leslie R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzo(a)pyrene Benzopyrenes - pharmacology Diazonium Compounds - pharmacology Dimethylnitrosamine - pharmacology DNA - biosynthesis DNA Repair Epoxy Compounds - pharmacology Liver - cytology Liver - drug effects Male Methyl Methanesulfonate - pharmacology Methylnitronitrosoguanidine - pharmacology Mutagens Rats Rats, Inbred Strains Uracil - analogs & derivatives Uracil - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	5-Diazouracil, which has been recommended in cancer chemotherapy, induced DNA repair synthesis in isolated rat hepatocytes. Repair synthesis was determined by means of the bromodeoxyuridine (BrdUrd)-CsCl-gradient centrifugation method. The validity of this technique was demonstrated using various DNA damaging compounds.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/0304-3835(81)90017-3