Epigallocatechin gallate with photodynamic therapy enhances anti-tumor effects in vivo and in vitro

Highlights • To evaluate anti-tumor effects of combined photodynamic therapy and epigallocatechin-3-gallate (EGCG). • The cell growth and the tumor volume in PDT combined with EGCG treatment group was significantly suppressed, compared with control and PDT or EGCG alone treated groups. • It is sugge...

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Veröffentlicht in:	Photodiagnosis and photodynamic therapy 2014-06, Vol.11 (2), p.141-147
Hauptverfasser:	Mun, Seong Taek, MD, PhD, Bae, Dong Han, Ahn, Woong Shick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-tumor effect Anticarcinogenic Agents - administration & dosage Catechin - administration & dosage Catechin - analogs & derivatives Cell Line, Tumor Cell Proliferation - drug effects Combined Modality Therapy Drug Combinations Drug Synergism EGCG Female Hematology, Oncology and Palliative Medicine Internal Medicine Mice Mice, Inbred C57BL Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - administration & dosage Porphyrins - administration & dosage Treatment Outcome Tumor Burden - drug effects
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Zusammenfassung:	Highlights • To evaluate anti-tumor effects of combined photodynamic therapy and epigallocatechin-3-gallate (EGCG). • The cell growth and the tumor volume in PDT combined with EGCG treatment group was significantly suppressed, compared with control and PDT or EGCG alone treated groups. • It is suggested that high anti-cancer activity of combined photodynamic therapy with EGCG may be useful for effective cancer therapy.
ISSN:	1572-1000 1873-1597
DOI:	10.1016/j.pdpdt.2014.03.003