Sarcosine preconditioning induces ischemic tolerance against global cerebral ischemia

Highlights • Sarcosine preconditioning reduced hippocampal cell death after cerebral ischemia. • Sarcosine preconditioning reduced glycine content and uptake in the hippocampus. • Sarcosine preconditioning reduced GlyT-1 and GlyT-2 expression in the hippocampus. • Sarcosine preconditioning reduced t...

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Veröffentlicht in:	Neuroscience 2014-06, Vol.271, p.160-169
Hauptverfasser:	Pinto, M.C.X, Simão, F, da Costa, F.L.P, Rosa, D.V, de Paiva, M.J.N, Resende, R.R, Romano-Silva, M.A, Gomez, M.V, Gomez, R.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Ischemia - drug therapy Brain Ischemia - pathology Brain Ischemia - physiopathology brain preconditioning Cell Death - drug effects Cell Death - physiology cerebral ischemia Disease Models, Animal Fundamental and applied biological sciences. Psychology Glycine - metabolism Glycine Plasma Membrane Transport Proteins - antagonists & inhibitors Glycine Plasma Membrane Transport Proteins - metabolism Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiopathology Male Medical sciences Neurology Neurons - drug effects Neurons - pathology Neurons - physiology neuroprotection Neuroprotective Agents - pharmacology neurotransmission and glycine transporter type 1 Rats, Wistar Receptors, N-Methyl-D-Aspartate - metabolism Sarcosine - pharmacology Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Sarcosine preconditioning reduced hippocampal cell death after cerebral ischemia. • Sarcosine preconditioning reduced glycine content and uptake in the hippocampus. • Sarcosine preconditioning reduced GlyT-1 and GlyT-2 expression in the hippocampus. • Sarcosine preconditioning reduced the expression of NR2B-containing NMDA receptors. • Sarcosine preconditioning induced ischemic tolerance against cerebral ischemia.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.04.054