Synthesis and biological evaluation of some new pyrazoline substituted benzenesulfonylurea/thiourea derivatives as anti-hyperglycaemic agents and aldose reductase inhibitors

Seventeen new pyrazoline substituted benzenesulfonylurea/thiourea derivatives (2a–q) were synthesized and characterized by elemental analysis and various spectroscopic techniques viz; IR, 1H NMR, 13C NMR, and MS data. Thirteen compounds showed moderate to good anti-hyperglycaemic activity in glucose...

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Veröffentlicht in:European journal of medicinal chemistry 2014-06, Vol.80, p.209-217
Hauptverfasser: Ovais, Syed, Pushpalatha, H., Reddy, G. Bhanuprakash, Rathore, Pooja, Bashir, Rafia, Yaseen, Shafiya, Dheyaa, Alhamza, Yaseen, Raed, Tanwar, Omprakash, Akthar, Mymoona, Samim, Mohammed, Javed, Kalim
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Sprache:eng
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Zusammenfassung:Seventeen new pyrazoline substituted benzenesulfonylurea/thiourea derivatives (2a–q) were synthesized and characterized by elemental analysis and various spectroscopic techniques viz; IR, 1H NMR, 13C NMR, and MS data. Thirteen compounds showed moderate to good anti-hyperglycaemic activity in glucose fed hyperglycaemic normal rats at the dose of 0.05 mM/kg b.w. On the basis of docking results nine compounds (2a, 2c, 2e, 2h, 2k, 2l, 2n, 2o and 2q) were evaluated for their ability to inhibit rat lens aldose reductase. Out of these six compounds (2h, 2k, 2l, 2n, 2o and 2q) were found more effective than the known ARI sorbinil. Five compounds (2h, 2k, 2l, 2n and 2o) showed significant dual action (anti-hyperglycaemic and aldose reductase inhibition). Five compounds (2h, 2k, 2l, 2n and 2o) showed significant dual action (anti-hyperglycaemic and ARI). Two compounds 2g and 2m showed anti-hyperglycaemic activity comparable to standard drug gliclazide. [Display omitted] •Seventeen new pyrazoline substituted benzenesulfonylurea/thiourea derivatives (2a–q) were synthesized.•Thirteen compounds showed moderate to good anti-hyperglycaemic activity.•Compounds 2g and 2m showed anti-hyperglycaemic activity comparable to the standard drug gliclazide.•Six compounds (2h, 2k, 2l, 2n, 2o and 2q) were found more effective ARIs than the known ARI sorbinil.•Five compounds (2h, 2k, 2l, 2n and 2o) showed dual action (anti-hyperglycaemic and aldose reductase inhibition).
ISSN:0223-5234
1768-3254
DOI:10.1016/j.ejmech.2014.04.046