Nanobody-based products as research and diagnostic tools

Highlights • New production platforms for VHH and VHH-Fc antibodies were recently explored. • VHHs have distinct properties and often outperform conventional antibodies. • Several VHHs for protein purification and localisation are commercially available.

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Bibliographische Detailangaben
Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2014-05, Vol.32 (5), p.263-270
Hauptverfasser:	De Meyer, Thomas, Muyldermans, Serge, Depicker, Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	antibody fragment Biological and medical sciences Biological Products - therapeutic use Biomedical Research - methods Biotechnology Clinical trials Cloning Fundamental and applied biological sciences. Psychology GFP-binding protein Growth hormones Humans Internal Medicine Leaves nanobody plant production platform Proteins recombinant protein production Seeds Single-Domain Antibodies Tobacco Viruses yeast production platform
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Beschreibung
Zusammenfassung:	Highlights • New production platforms for VHH and VHH-Fc antibodies were recently explored. • VHHs have distinct properties and often outperform conventional antibodies. • Several VHHs for protein purification and localisation are commercially available.
ISSN:	0167-7799 1879-3096
DOI:	10.1016/j.tibtech.2014.03.001