Chloroform inhibition of 1,2-dimethylhydrazine-induced gastrointestinal tract tumors in the fisher 344 rat

The effect of chloroform (CHCl 3), administered at 0,900, and 1800 mg/liter in the drinking water, on the carcinogenic potency of 1,2-dimethylhydrazine (DMH) was investigated. Groups of 40 male Fisher 344 rats were given one of the three drinking water solutions for 39 weeks following the subcutaneo...

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Veröffentlicht in:Fundamental and applied toxicology 1989-07, Vol.13 (1), p.40-45
Hauptverfasser: Bernard Daniel, F., DeAngelo, Anthony B., Stober, Judy A., Pereira, Michael A., Olson, Gregory R.
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Sprache:eng
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Zusammenfassung:The effect of chloroform (CHCl 3), administered at 0,900, and 1800 mg/liter in the drinking water, on the carcinogenic potency of 1,2-dimethylhydrazine (DMH) was investigated. Groups of 40 male Fisher 344 rats were given one of the three drinking water solutions for 39 weeks following the subcutaneous injection of 200 mg/kg DMH, a known gastrointestinal (GI) tract carcinogen in this animal strain. When tumors from the GI tract were pooled there was a highly significant ( p < 0.001) decrease in total number of tumors per group with increasing concentration of drinking water CHCl 3. In the control group (0 mg/liter CHCl 3), 14 39 (36%) of the animals developed tumors of the GI tract, including the duodenum, jejunum, stomach, cecum, and colon. In contrast, the incidence of tumors in the two groups of rats given CHCl 3 in the drinking water was significantly lower ( p < 0.001; 900 mg/liter CHCl 3, 12.8%; 1800 mg/liter CHCl 3, 12.5%). A similar relationship was obtained when colon tumors were analyzed independently ( p = 0.01). The incidence of total colon tumors obtained in the control group of this study ( 10 39 , 26%) agrees well with the previous study by B.S. Reddy, K. Watanabe, and J. H. Weisburger (1977, Cancer Res. 37, 4156–4159) conducted in the same rat strain ( 7 30 , 23%). These results demonstrate that CHCl 3 in the drinking water inhibits carcinogenesis in the rat GI tract.
ISSN:0272-0590
1095-6832
DOI:10.1016/0272-0590(89)90305-9