Chloroform inhibition of 1,2-dimethylhydrazine-induced gastrointestinal tract tumors in the fisher 344 rat
The effect of chloroform (CHCl 3), administered at 0,900, and 1800 mg/liter in the drinking water, on the carcinogenic potency of 1,2-dimethylhydrazine (DMH) was investigated. Groups of 40 male Fisher 344 rats were given one of the three drinking water solutions for 39 weeks following the subcutaneo...
Gespeichert in:
Veröffentlicht in: | Fundamental and applied toxicology 1989-07, Vol.13 (1), p.40-45 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | The effect of chloroform (CHCl
3), administered at 0,900, and 1800 mg/liter in the drinking water, on the carcinogenic potency of 1,2-dimethylhydrazine (DMH) was investigated. Groups of 40 male Fisher 344 rats were given one of the three drinking water solutions for 39 weeks following the subcutaneous injection of 200 mg/kg DMH, a known gastrointestinal (GI) tract carcinogen in this animal strain. When tumors from the GI tract were pooled there was a highly significant (
p < 0.001) decrease in total number of tumors per group with increasing concentration of drinking water CHCl
3. In the control group (0 mg/liter CHCl
3),
14
39
(36%) of the animals developed tumors of the GI tract, including the duodenum, jejunum, stomach, cecum, and colon. In contrast, the incidence of tumors in the two groups of rats given CHCl
3 in the drinking water was significantly lower (
p < 0.001; 900 mg/liter CHCl
3, 12.8%; 1800 mg/liter CHCl
3, 12.5%). A similar relationship was obtained when colon tumors were analyzed independently (
p = 0.01). The incidence of total colon tumors obtained in the control group of this study (
10
39
, 26%) agrees well with the previous study by B.S. Reddy, K. Watanabe, and J. H. Weisburger (1977,
Cancer Res.
37, 4156–4159) conducted in the same rat strain (
7
30
, 23%). These results demonstrate that CHCl
3 in the drinking water inhibits carcinogenesis in the rat GI tract. |
---|---|
ISSN: | 0272-0590 1095-6832 |
DOI: | 10.1016/0272-0590(89)90305-9 |