Effect of hepatic irradiation on the toxicity and pharmacokinetics of adriamycin in children

Effect of hepatic irradiation on the toxicity and pharmacokinetics of adriamycin in children

The effect of hepatic irradiation on adriamycin toxicity and pharmacokinetics was studied in 10 children who received adriamycin with concurrent abdominal irradiation for Wilms' tumor. Hepatic irradiation to 2400–2700 rad at 100–150 rad per fraction did not alter the clinical toxicity or plasma...

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Veröffentlicht in:Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1981-07, Vol.7 (7), p.953-956
Hauptverfasser: Holcenberg, John S., Kun, Larry E., Ring, Barbara J., Evans, William E.
Format: Artikel
Sprache:eng
Schlagworte:
550603 - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man
Adriamycin
AGE GROUPS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTINEOPLASTIC DRUGS
BODY
Child
Child, Preschool
CHILDREN
DIGESTIVE SYSTEM
DISEASES
DOXORUBICIN
Doxorubicin - metabolism
Doxorubicin - toxicity
DRUGS
FRACTIONATED IRRADIATION
GLANDS
Half-Life
HEMIC DISEASES
Hepatic irradiation
Humans
IRRADIATION
Kidney Neoplasms - therapy
LEUKOPENIA
LIVER
Liver - radiation effects
MEDICINE
NAUSEA
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
Pharmacokinetics
PHARMACOLOGY
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
RADIOINDUCTION
RADIOLOGY
RADIOLOGY AND NUCLEAR MEDICINE
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SIDE EFFECTS
SURGERY
SYMPTOMS
THERAPY
Toxicity
VOMITING
Wilms Tumor - therapy
Wilms' tumor
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Beschreibung
Zusammenfassung:The effect of hepatic irradiation on adriamycin toxicity and pharmacokinetics was studied in 10 children who received adriamycin with concurrent abdominal irradiation for Wilms' tumor. Hepatic irradiation to 2400–2700 rad at 100–150 rad per fraction did not alter the clinical toxicity or plasma pharmacokinetics of adriamycin.
ISSN:0360-3016
1879-355X
DOI:10.1016/0360-3016(81)90015-8