A quantitative analysis of alterations in the shape of cultured fibroblasts induced by tumour-promoting phorbol ester

Quantitative analysis of cell size and shape has shown that the tumour promotor 12-o-tetradecanoylphorbol-13-acetate (TPA) alters one of three parameters of cell shape, dispersion. It has no effect on cell area or elongation. This reflects the fact that TPA causes cells to form long narrow processes...

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Veröffentlicht in:	Cell biology international reports 1989-04, Vol.13 (4), p.357-366
Hauptverfasser:	Brown, A.F., Dugina, V., Dunn, G.A., Vasiliev, J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Cell physiology fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fundamental and applied biological sciences. Psychology Mice Molecular and cellular biology Mutagens - pharmacology Responses to growth factors, tumor promotors, other factors Tetradecanoylphorbol Acetate - pharmacology
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Beschreibung
Zusammenfassung:	Quantitative analysis of cell size and shape has shown that the tumour promotor 12-o-tetradecanoylphorbol-13-acetate (TPA) alters one of three parameters of cell shape, dispersion. It has no effect on cell area or elongation. This reflects the fact that TPA causes cells to form long narrow processes extending from the cell body. The ability to measure alterations in specific parameters of cell shape is important for correlating changes in the observed behaviour of cells with effects on cytoskeletal organisation.
ISSN:	0309-1651 1878-240X
DOI:	10.1016/0309-1651(89)90162-8