Charybdotoxin blocks dendrotoxin-sensitive voltage-activated K super(+) channels

Charybdotoxin blocks dendrotoxin-sensitive voltage-activated K super(+) channels

Charybdotoxin, a short scorpion venom neurotoxin, which was thought to be specific for the blockade of Ca super(2+)-activated K super(+) channels also blocks a class of voltage-sensitive K super(+) channels that are known to be the target of other peptide neurotoxins from snake and bee venoms such a...

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Veröffentlicht in:FEBS letters 1989-01, Vol.250 (2), p.519-522
Hauptverfasser: Schweitz, H, Stansfeld, CE, Bidard, J-N, Fagni, L, Maes, P, Lazdunski, M
Format: Artikel
Sprache:eng
Schlagworte:
Leiurus quinquestriatus hebraeus
nervous system
potassium
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Zusammenfassung:Charybdotoxin, a short scorpion venom neurotoxin, which was thought to be specific for the blockade of Ca super(2+)-activated K super(+) channels also blocks a class of voltage-sensitive K super(+) channels that are known to be the target of other peptide neurotoxins from snake and bee venoms such as dendrotoxin and MCD peptide. Charybdotoxin also inhibits super(125)I-dendrotoxin and super(125)I-MCD peptide binding to their receptors. All these effects are observed with an IC sub(50) of about 30 nM.
ISSN:0014-5793