The biology of APOL1 with insights into the association between APOL1 variants and chronic kidney disease

Recent studies have identified genetic variants in APOL1 that may contribute to the increased incidence of kidney disease in populations with African ancestry. Here, we review the biology of APOL1 present in the circulation and localized to the kidney as it may contribute to the pathogenesis of APOL...

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Veröffentlicht in:	Clinical and experimental nephrology 2014-04, Vol.18 (2), p.238-242
Hauptverfasser:	Madhavan, Sethu M, O'Toole, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	African Continental Ancestry Group - genetics Apolipoprotein L1 Apolipoproteins - blood Apolipoproteins - genetics Genetic Variation Humans Lipoproteins, HDL - blood Lipoproteins, HDL - genetics Medicine Medicine & Public Health Nephrology Polymorphism, Single Nucleotide Renal Insufficiency, Chronic - genetics Review Article Trypanosoma brucei gambiense Trypanosomiasis, African - genetics Urology
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Zusammenfassung:	Recent studies have identified genetic variants in APOL1 that may contribute to the increased incidence of kidney disease in populations with African ancestry. Here, we review the biology of APOL1 present in the circulation and localized to the kidney as it may contribute to the pathogenesis of APOL1-associated kidney disease.
ISSN:	1342-1751 1437-7799
DOI:	10.1007/s10157-013-0907-4