Antimicrobial Resistance and Virulence-Associated Genes of Salmonella enterica Subsp. enterica Serotypes Muenster, Florian, Omuna, and Noya Strains Isolated from Clinically Diarrheic Humans in Egypt
Four serotypes recovered from clinically diarrheic human faecal samples ( Salmonella Muenster, Salmonella Florian, Salmonella Omuna and Salmonella Noya) were investigated for the presence of 11 virulence genes ( inv A , avr A, ssa Q, mgt C, sii D, sop B, gip A, sod C1, sop E1, spv C, and bcf C) and...
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Veröffentlicht in: | Microbial drug resistance (Larchmont, N.Y.) N.Y.), 2013-10, Vol.19 (5), p.37-377 |
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Zusammenfassung: | Four serotypes recovered from clinically diarrheic human faecal samples (
Salmonella
Muenster,
Salmonella
Florian,
Salmonella
Omuna and
Salmonella
Noya) were investigated for the presence of 11 virulence genes (
inv
A
, avr
A,
ssa
Q,
mgt
C,
sii
D,
sop
B,
gip
A,
sod
C1,
sop
E1,
spv
C, and
bcf
C) and their association with antibiotic resistance. The 4
Salmonella
serotypes lacked virulence genes
gip
A and
spv
C. Resistance to 7 of the 14 antimicrobials was detected. The frequency of resistance, to lincomycin and streptomycin (100% of the
Salmonella
Muenster [2/5],
Salmonella
Florian [1/5],
Salmonella
Omuna [1/5], and
Salmonella
Noya [1/5] isolates), chloramphenicol (100% of the
Salmonella
Muenster [2/5] and
Salmonella
Florian [1/5] isolates) and trimethoprim–sulfamethoxazole (100% of the
Salmonella
Florian [1/5] and
Salmonella
Omuna [1/5] isolates) was an outstanding feature. With the rest of the antibiotics, the four
Salmonella
serotypes exhibited a great diversity in their resistance patterns. Overall, the four
Salmonella
serotypes were resistant to more than one antimicrobial. The antimicrobials to which the
Salmonella
Muenster,
Salmonella
Florian, and
Salmonella
Omuna isolates were resistant, contributed to five different antimicrobial resistance profiles. The virulence associated genes
inv
A,
ssa
Q,
sii
D,
sop
B, and
bcf
C genes were 100% associated with certain antimicrobial resistance phenotypes (streptomycin and lincosamide) not recorded previously, and secondly, the presence of
inv
A,
avr
A,
ssa
Q,
mgt
C,
sii
D,
sop
B, and
bcf
C was associated with resistance to chloramphenicol. The results of this study will help in understanding the spread of virulence genotypes and antibiotic resistance in
Salmonella
in the region of study. |
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ISSN: | 1076-6294 1931-8448 |
DOI: | 10.1089/mdr.2012.0151 |