Understanding the Colloidal Stability of the Mesoporous MIL-100(Fe) Nanoparticles in Physiological Media

Understanding the Colloidal Stability of the Mesoporous MIL-100(Fe) Nanoparticles in Physiological Media

The colloidal and chemical stability of nanoparticles of the nontoxic and biodegradable iron­(III) trimesate MIL-100­(Fe) nanocarrier have been evaluated in the presence of a series of simulated physiological fluids for intravenous and oral administration. MIL-100­(Fe) nanoparticles exhibit an appro...

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Veröffentlicht in:Langmuir 2014-05, Vol.30 (20), p.5911-5920
Hauptverfasser: Bellido, Elena, Guillevic, Mazheva, Hidalgo, Tania, Santander-Ortega, Manuel J, Serre, Christian, Horcajada, Patricia
Format: Artikel
Sprache:eng
Schlagworte:
Colloids
Drug Carriers - chemistry
Drug Stability
Iron - chemistry
Metal Nanoparticles - chemistry
Tricarboxylic Acids - chemistry
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Zusammenfassung:The colloidal and chemical stability of nanoparticles of the nontoxic and biodegradable iron­(III) trimesate MIL-100­(Fe) nanocarrier have been evaluated in the presence of a series of simulated physiological fluids for intravenous and oral administration. MIL-100­(Fe) nanoparticles exhibit an appropriate colloidal stability and biodegradability, mainly dependent on both the nature of their physicochemical surface and the media composition, being a priori compatible with their biomedical use.
ISSN:0743-7463
1520-5827
DOI:10.1021/la5012555