Pinostrobin and Cajanus lactone isolated from Cajanus cajan (L.) leaves inhibits TNF-α and IL-1β production: In vitro and in vivo experimentation

Pinostrobin and Cajanus lactone isolated from Cajanus cajan (L.) leaves inhibits TNF-α and IL-1β production: In vitro and in vivo experimentation

The tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) inhibitory activities of Cajanus cajan (leaves) crude methanolic extract, its fractions and its phytochemical constituents were evaluated in lipopolysaccharide (LPS) stimulated RAW 264.7 and J774A.1 cells. Phytochemical investiga...

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Veröffentlicht in:Phytomedicine (Stuttgart) 2014-06, Vol.21 (7), p.946-953
Hauptverfasser: Patel, Neeraj K., Bhutani, Kamlesh K.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anti-Inflammatory Agents, Non-Steroidal - isolation & purification
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Botanical research
Cajanus - chemistry
Cajanus cajan
Cajanus lactone
Care and treatment
Cell Line - drug effects
Coumarins - chemistry
Coumarins - isolation & purification
Coumarins - pharmacology
Cytokines - blood
Female
Flavanones - isolation & purification
Flavanones - pharmacology
Health aspects
Inflammation
Inflammation - drug therapy
Inflammation - metabolism
Inhibitory Concentration 50
Interleukin-1beta - antagonists & inhibitors
Interleukin-1beta - metabolism
Interleukin-1β
Lipopolysaccharides - pharmacology
Materia medica, Vegetable
Mice
Molecular Structure
Phytochemistry
Pigeon pea
Pinostrobin
Plant extracts
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
Rats, Sprague-Dawley
Stilbenes
Tumor Necrosis Factor-alpha - metabolism
tumor necrosis factor-α
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Zusammenfassung:The tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) inhibitory activities of Cajanus cajan (leaves) crude methanolic extract, its fractions and its phytochemical constituents were evaluated in lipopolysaccharide (LPS) stimulated RAW 264.7 and J774A.1 cells. Phytochemical investigation of the active ethyl acetate (CCE) and n-butanol (CCB) fractions of C. cajan L. leaves yielded 14 compounds. It was observed that both pinostrobin (9) and cajanus lactone (4) were found to be most active in inhibiting TNF-α (IC50
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2014.02.011