Modulating Noncatalytic Function with Kinase Inhibitors

In this issue of Chemistry & Biology, Hari and colleagues show that conformation-selective ATP-competitive kinase inhibitors have distinct noncatalytic effects on Erk2, including the ability to modulate protein-protein interactions outside the ATP-binding site. These findings enhance our knowled...

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Veröffentlicht in:	Chemistry & biology 2014-05, Vol.21 (5), p.569-571
Hauptverfasser:	Agius, Michael P., Soellner, Matthew B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - antagonists & inhibitors Humans Mitogen-Activated Protein Kinases - antagonists & inhibitors Protein Kinase Inhibitors - pharmacology
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Beschreibung
Zusammenfassung:	In this issue of Chemistry & Biology, Hari and colleagues show that conformation-selective ATP-competitive kinase inhibitors have distinct noncatalytic effects on Erk2, including the ability to modulate protein-protein interactions outside the ATP-binding site. These findings enhance our knowledge about the diverse array of activities in which kinase inhibitors can target signaling pathways.
ISSN:	1074-5521 1879-1301
DOI:	10.1016/j.chembiol.2014.05.005