The developmental disruptions of serotonin signaling may involved in autism during early brain development

The developmental disruptions of serotonin signaling may involved in autism during early brain development

Highlights • Developmental disruptions of serotonin signaling involved in autism. • Hyperserotonemia provokes a loss of serotonin terminals. • Deficiency of the serotonergic system induces mis-wiring of neural network.

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Bibliographische Detailangaben
Veröffentlicht in:Neuroscience 2014-05, Vol.267, p.1-10
Hauptverfasser: Yang, C.-J, Tan, H.-P, Du, Y.-J
Format: Artikel
Sprache:eng
Schlagworte:
autism
Autistic Disorder - pathology
Biological and medical sciences
Brain - growth & development
Brain - pathology
calcitonin gene-related peptide
Developmental Disabilities - pathology
Fundamental and applied biological sciences. Psychology
Humans
hyperserotonemia
hyposerotonemia
Neurology
oxytocin
serotonin
Serotonin - metabolism
Signal Transduction - physiology
Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:Highlights • Developmental disruptions of serotonin signaling involved in autism. • Hyperserotonemia provokes a loss of serotonin terminals. • Deficiency of the serotonergic system induces mis-wiring of neural network.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.02.021