Developing biomarkers for cerebral amyloid angiopathy trials: do potential disease phenotypes hold promise?

Cerebral amyloid angiopathy type 1 (especially capillary, more than arteriolar) seems to be associated with parenchymal amyloid deposition in Alzheimer's disease, and might cause luminal obstruction in the most severe stages, potentially explaining the low incidence of microbleeds and intracerebral haemorrhage in patients with Alzheimer's disease, and the association between microinfarcts and cognitive impairment in cerebral amyloid angiopathy. [...]APOE genotype probably affects the phenotype of cerebral amyloid angiopathy, but it is likely that this is not the whole story.