The hydroxylation and dealkylation of some naphthyl alkyl ethers by rat liver microsomes

1. The dealkylation and side-chain hydroxylation of 1 -(4-acetylnaphthyl) ethers by rat liver microsomes is described. The proportions of compounds metabolized by both routes are determined and shown to vary according to the length of the alkyl side-chain. 2. Metabolites formed by side-chain hydroxy...

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Veröffentlicht in:	Xenobiotica 1981-01, Vol.11 (3), p.179-188
Hauptverfasser:	Hunter, W. H., Wilson, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dealkylation Ethers - metabolism Hydroxylation In Vitro Techniques Kinetics Microsomes, Liver - metabolism Naphthalenes - metabolism Rats Rats, Inbred Strains Solubility
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Zusammenfassung:	1. The dealkylation and side-chain hydroxylation of 1 -(4-acetylnaphthyl) ethers by rat liver microsomes is described. The proportions of compounds metabolized by both routes are determined and shown to vary according to the length of the alkyl side-chain. 2. Metabolites formed by side-chain hydroxylation are identified by g.l.c.-mass spectrometry and by comparison with authentic materials.
ISSN:	0049-8254 1366-5928
DOI:	10.3109/00498258109045290