Differential changes in rat brain tryptophan, serotonin and tyrosine levels following acute aflatoxin B1 treatment

Female Sprague-Dawley rats were treated acutely (12-h) with aflatoxin B1 (100 micrograms/kg i.p.) or vehicle (10% acetone in 0.9% NaCl) and regional brain levels of tryptophan, serotonin and tyrosine were assayed. Brainstem but not cerebellar or cortical tyrosine levels were decreased in aflatoxin B...

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Veröffentlicht in:	Toxicology letters 1989-05, Vol.47 (2), p.173-177
Hauptverfasser:	Weekley, L.B, O'Rear, C.E, Kimbrough, T.D, Llewellyn, G.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxin B1 aflatoxins Aflatoxins - toxicity Animals Biological and medical sciences brain Brain - drug effects Brain - metabolism carcinogens Carcinogens - toxicity Female Injections, Intraperitoneal Medical sciences Plant poisons toxicology Rats Rats, Inbred Strains serotonin Serotonin - metabolism Toxicology tryptophan Tryptophan - metabolism tyrosine Tyrosine - metabolism
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